A facile preparation of trisubstituted amino-furan and -thiophene derivatives.
نویسندگان
چکیده
β-Alkylation of amino-furan and -thiophene heterocycles is described through metal-, acid- and base-free carbon-carbon bond formation. The ability of both heterocycles to undergo selective β-alkylation is compared by mean of experimental and theoretical data. The presence of chiral amine substituents induced the diastereoselective generation of the newly formed additional stereocenter.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 17 شماره
صفحات -
تاریخ انتشار 2011